For the first 10 or so years that I hunted the only CF rifle that I had was a .30-06. I loaded it with 150 grain bullets for mule deer and antelope, and 180 grain bullets for elk. That got to be a pain re-zeroing for each animal, and since deer and elk seasons were at the same time, I often ended up killing both my deer and elk with the same weight bullet.
I then had my .30-06 re-chambered to .30 Gibbs for elk and just loaded 180 grain Partitions in it. I ended up killing elk, moose, and caribou with that combination.
At the same time I built a .257 Roberts Ackley Improved for deer and antelope. Over the years I've tried a variety of 115-120 grain bullets in it, but the bullet that I've killed the most deer and antelope with, and elk, caribou, and several mountain sheep, is the 117 grain Sierra GameKing.
About 20 years ago I bought a 7 mm Rem mag in stainless steel and a plastic stock. So far I have only used 160 grain Nosler Accubond bullets in it for hunting. Because it is more weather intolerant than my fancy walnut shocked rifles, I probably use it more now than any of my other rifles. I have used it here in Montana for deer, antelope, and elk, and on a number of hunts in African and Canada. It is a "do it all" caliber and rifle.
My favorite rifle is my .300 Weatherby that I've used with 168 grain Barnes TSX and TTSX bullets here in Montana and on five international hunts, killing a variety of animals from 20 pound African antelope to bull elk. It truly is also a "do it all" caliber and rifle.
In 50 years of very successful Western and international hunting, I have never killed an animal at a range of over 350 yards.