Central Colorado can be more mountainous, containing habitats from river bottoms to alpine tundra, and lots in between. The mountainous areas are not all thick timber, but they are not usually as open country as 22, either.
22 is located on the Roan Plateau, a semi-arid plateau with deeply incised canyons. This photo I found online is textbook GMU22.
View attachment 70479 Much more oak brush, service berry, pinion/juniper, sagebrush habitat than the central mountains. It's not what I would call "sparse". It's open country, which allows you to glass from the ridges and see a long way. But, once you find the critters you have to get to them. And that oak brush is thick, thick, thick.
I don't think either is "better" for a rookie, they are just different.