I really , really , like the 6.5 PRC.
But , if I were wanting reliable penetration , at most all angles at longer distance, and especially on big animals weighing 400+ pounds....
There would only be three cartridges I would choose from.
.300 win mag
.300 ultra mag
.300 PRC
In that order also is my preference.
I have taken game close to 600yrds. many times with my .300 am in a Wnchester M70.
Mostly deer size. No elk as of yet.
Many of those deer went 50-60 yrds before pilling up.
An elk will likely take a hit at those distance's with little to no reaction and possibly go down when he feels like it. Which might not be in sight anymore.
At a thousand yrds that possible scenario may make finding your animal awfully hard.
In rough thick terrain it would be almost impossible.
So at distance's over 500yrds , more gun is always better.
I can hit targets pretty reliable out to 850yrds , but wouldn't try an animal at that distance.
Too many variables to ethically get it done.
Wind can be impossible to make a shot go where you want or think a bullet will go, without multiple tries and dope adjustment.
The 6.5 PRC is very capable. But I would want 180+grain bullets at very long distances on targets or game. That ensures wind cutting abilities and energy on targets.
Personal ability is always a factor. But even the best shooter using the best equipment won't always be able to make perfect hits past 600yrds.