I started using Barnes bullets back in 2005 in my .375 RUM for a Cape Buffalo hunt in Zimbabwe. My buffalo was a one shot kill with a 300 grain TSX. On a second African hunt with that rifle for just plains game, I used 270 grain TSX bullets. I was happy with the performance of both of those bullets on the 16 animals that I shot with them.
Bullet placement is very important regardless of what bullet you use.
When I built my .300 Weatherby in 2009 I decided to use Barnes bullets in it because I had had such good performance from Barnes bullets in my .375 RUM.
I started off using 168 grain TSX bullets, then 168 grain TTSX bullets, and now I am using 180 grain TTSX bullets. I only hunt with these bullets in my .300 Wby, and have used them on 5 international hunts and a number of hunts here at home.
I have only shot 2 bull elk with Barnes bullets, one with a 168 grain TSX and one with a 168 grain TTSX. Both shots were under 200 yards, were one shot kills, and both bulls fell dead less than 10 yards from where they were shot.
Of the 40-50 animals that I've shot with Barnes bullets, I've only recovered 8 bullets. All were the classic Barnes mushroom, but 3 had one petal broken off, presumably from hitting a large bone. We didn't look for the bullets in all animals, but I think most of them passed completely through the animals, including the 168 grain TSX from one of the bull elk. That bullet passed just behind both of his front legs, and he only took 3 steps and fell dead. Again, bullet placement is very important.
I've been able to work up sub-moa 3-shot groups with all of these Barnes bullets, which meets my criteria for hunting.