I have scopes with CDS turrets on 5 of my rifles. I like them, a lot! For the scope on my .300 Weatherby, I sent the bullet and range data back to the scope manufacturer and they made a turret for my specific bullet and load, so I can just dial the distance on the turret and shoot. The custom turret for that scope came back with a Zero lock at 200 yards, so for most hunting situations, I have a pbr of about 350 yards with the range turret set at zero. All of these scopes have hash marks on the horizontal cross hair, so I use these for wind instead of trying to dial it in.
I have not had custom turrets made for my other scopes, but for each of them I zeroed the rifles at 100 yards and locked those turrets so that their zero setting is dead on at 100 yards. Then I painted a round white dot in top of the turret, over the zero mark. Then I range verified what turret setting for bullet impacts at 200, 300, and 430 yards (the furthest target berm at our range). I then used a needle and painted a fine white line on the top of the turret caps for those ranges.
I have never killed an animal further away that 350 yards, so with my system I don't have to read the little numbers etched around the side of my turrets or worry about minutes or mils. I just range my target, set the turret top hash mark that is closest to that range, pick the windage hash mark on the horizontal cross hair, and shoot.