The difference between the tough to draw units and and the easy to draw units is public land percentage and the number of trophy bucks per 100 does.
For instance, in area 64, you have almost all public land and you'll find a trophy (80+ B&C) buck for about every 100 bucks (from my experience). On the other hand, in area 48, you'll have to figure out the HMA/Walk-In situation and poke around the private pieces with your GPS to make sure you're legal (or call ranchers for access). Also, you'll only see about one trophy buck for every 300 bucks that you find.
This is just to say that there's good hunting in a lot of areas in Wyoming and that you should really just adjust your expectations accordingly and go hunt because you never know when you won't get to go anymore. My Dad and I apply for the best units we can every year in an attempt to use our points as soon as we can. We haven't drawn the last two years. Next year I'll have 2 and he'll have 3. We'll try to apply for the best units we can with that number of points and draw a tag so we can hunt. Points are only as good as the utility value they provide. Accumulating points seems to be a game for some people where the goal is just to have the most points. I don't understand it.
I killed my 91-2/8 B&C buck in an area that I drew with 0 points. I killed an 86 4/8 B&C in an area that now takes max points to draw.
Good luck with whatever route you go.