Slightly, but buy and shoot what you want and enjoy it. Especially if you reload. Reloading and revolvers go together like they were made for eachother. If your buying factory ammo only you may want to consider the cost and availability of factory ammo and think about practicing too. Reloading opens things up, brings costs down, enables you to make less powerful ammo to practice with. Factory ammo only the 44 will be more cost effective and you can get 44 special. Not sure if there's a "special" version for those cartridges.
The 44s what I have, I've shot a hog with it and take it deer hunting sometimes. I personally think the 44s great. It's also an old cartridge that's watered down slightly by most factory ammo. If I'm hunting I'd either use Buffalo bore/underwood ammo or what I do is hunt with 240gr xtps over 26ish grains of w296 to get the full potential.