I have only hunted with one caliber all of my life (45+ years) It is the .270. It has never let me down!
For me, the answer to this post lies these few question. Do you reload? Is most of your hunting in open country or tight country? What is your max sized game animal? Are you basing your answer on reality or fantasy?
If one reloads, the 280 AI has all the math and powder efficiency anyone could ever ask for, It is the 95 % equivalent of the 7 mag with so MUCH less powder, recoil and comes in light rifles
If you hunt in less open country the.308 is so just plain doable. It is also so efficient and accurate.
If you stay with deer and antelope, and like to stalk the sweet Swede 6.5x55 works admirably.
I have loved both the 30-06 and .270 forever.
With the use of monolythic all copper bullets, all calibers can get an upgrade. Copper bullets with their sharp spinning petals cut/drill their way through game. A huge efficiency surge over lead bullets, which now reminds me of shaving with a dull razor. The reviews of such bullets as Barnes from African Professional hunters are glowing.
That makes the .270 now the equal of the 30-06.
The only problem with the,270 is that Lapua does not make an all copper Naturaiis bullet for the .270.
Those bullets are such great killers and so kind to meat. In times gone by I used 180 grain Barnes round nosed originals in my .270 when hunting antelope in high mountain meadows in Grizz country of NW Wyoming where I once lived
Some fellows are just going to be hooked on the myth and glory of huge, big calibers that they will never have need for.
I would say flip a coin between the .270 and .308 and add in this thought. Hunting the west has become more like hunting the east.
Despite all the long-range shooting Hoopla, and even because of it, the increased hunting pressure has caused game animals to respond with the “Ecology of Fear” and seek the safety of tighter county.