mrna and cwd?

[Dougfirtree]

This may sound like a stupid question, but I was just reading something about all the potential diseases that may be preventable with mrna vaccines and how the COVID vaccine research has launched us forward in terms of data and research, setting us up for something of a vaccine revolution.
Has anyone ever heard a reputable theory that CWD could be attacked in this way? I know there's been research into a vaccine for CWD... Just curious and I know there are some smart, plugged-in folks on here.

 

[Jason73]

Vaccines that change your DNA, even though I'm no scientist, makes me leary. Personally waiting to see how this covid one plays out over time.

 

[Deleted member 38069]

Vaccines that change your DNA, even though I'm no scientist, makes me leary. Personally waiting to see how this covid one plays out over time.

Coronavirus Resource Center - Harvard Health

COVID-19 (coronavirus disease 2019) is a respiratory illness caused by the SARS-CoV-2 virus. It is very contagious, and spreads quickly. Most people with COVID-19 have mild respiratory symptoms that feel much like a cold or flu. But it can be much more serious for older adults, people with...

www.health.harvard.edu

 

[np307]

CWD isn't caused by a virus. Its caused by a prion. Very different worlds.

 

[Dougfirtree]

Vaccines that change your DNA, even though I'm no scientist, makes me leary. Personally waiting to see how this covid one plays out over time.

Well, I don't want to turn this thread into an argument on the COVID 19 vaccine, but it doesn't change your DNA, or even interact with it.

 

[Dougfirtree]

CWD isn't caused by a virus. Its caused by a prion. Very different worlds.

True, but I'm not sure that the potential uses of mrna type vaccines are limited to viruses. Seems like it could potentially be used to combat almost anything capable of creating an immune response. I'm not sure whether deer have any immune response to CWD-causing prions, though.

 

[Deleted member 38069]

From my minuscule knowledge, CWD and Alzheimer’s are similar in that prions cause essential proteins to denature. This is why it’s difficult to put a thumb on either.

 

[np307]

True, but I'm not sure that the potential uses of mrna type vaccines are limited to viruses. Seems like it could potentially be used to combat almost anything capable of creating an immune response. I'm not sure whether deer have any immune response to CWD-causing prions, though.

They don't. The prions literally change the way that other proteins in the brain unfold. The biology is way way way different from viral or bacterial infections.

 

[Jason73]

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Coronavirus Resource Center - Harvard Health

COVID-19 (coronavirus disease 2019) is a respiratory illness caused by the SARS-CoV-2 virus. It is very contagious, and spreads quickly. Most people with COVID-19 have mild respiratory symptoms that feel much like a cold or flu. But it can be much more serious for older adults, people with...

www.health.harvard.edu

Worded incorrectly, as stated, not a scientist. Listening to my med school kid gets over my head. Regardless it's an entirely new way to vaccinate and I'll prefer to wait it out. Yeah it was a crappy sickness but not that crappy.

 

[morley.tyler]

even though I'm no scientist

You had me at 'Hello'

 

[AvidIndoorsman]

Worded incorrectly, as stated, not a scientist. Listening to my med school kid gets over my head. Regardless it's an entirely new way to vaccinate and I'll prefer to wait it out. Yeah it was a crappy sickness but not that crappy.

A traditional vaccine works by injecting a dead or weakened virus into your body. Your body fights that off and then stores the information about how to fight that virus.

An mRNA vaccine works by injecting mRNA for a spike protein into your body. The mRNA will enter muscle cells at the site and some of them will create the spike protein. Your body then destroys these cells, and retains the information to destroy other spike proteins. Essentially you are never at risk of getting sick from the vaccine because it's just teaching your body what to look for to destroy rather than providing the actual pathogen.

The mRNA does not enter the nucleus of the cell where your DNA is located.

@Dougfirtree I think the antibody therapy some people who had Covid-19 received are more in line with what a treatment for CWD would be like rather than the mRNA vaccines.

 

[geewhiz]

This is going to turn into one of those threads isnt it...

 

[SAJ-99]

They don't. The prions literally change the way that other proteins in the brain unfold. The biology is way way way different from viral or bacterial infections.

This ^ is my guess. I am not saying it isn't possible, but I don't think the body forms an immune response to CWD. I think it kind of destroys the brain and nervous cell tissues through the broken proteins. That is why perfectly normal looking deer can test positive if they are early in their exposure.

 

[Deleted member 38069]

Worded incorrectly, as stated, not a scientist. Listening to my med school kid gets over my head. Regardless it's an entirely new way to vaccinate and I'll prefer to wait it out. Yeah it was a crappy sickness but not that crappy.

Ask your kid how transcription and translation works.

 

[AvidIndoorsman]

This ^ is my guess. I am not saying it isn't possible, but I don't think the body forms an immune response to CWD. I think it kind of destroys the brain and nervous cell tissues through the broken proteins. That is why perfectly normal looking deer can test positive if they are early in their exposure.

I'm also not sure how you would get an antibody through the blood brain barrier.

 

[thusby]

Sitting here infected, after being fully vaccinated, my blood coagulated into napalm. Just saying.

 

[Gr8bawana]

Vaccines that change your DNA, even though I'm no scientist, makes me leary. Personally waiting to see how this covid one plays out over time.

 

[Deleted member 38069]

Hope this helps! I’m a visual learner

 

[Dougfirtree]

Sitting here infected, after being fully vaccinated, my blood coagulated into napalm. Just saying.

That sucks. Never fun to be in that unlucky minority. Hope you feel better soon!

 

[88man]

correct, however possibilities of a virus causing the formation of a prion