I carried a 7 1/2" Ruger SBH loaded with 250 grain Lyman 429421 gas checked over 23 grins of WW 296 for quite a few years. Made a spot and stalk one shot kill on one black bear with it. Many years ago when I lived in NW Montana I carried this pistol and my fishing partner carried a .357. Sometimes we would stop for a break and shoot rocks. His .357 would nock the rocks over and maybe break the rock in half, my .44 would turn the rocks into gravel.
Also for quite a few years I carried a Govt model 1911 loaded with 220 grain Lyman 452460 SWC bullets over 6.4 grains of Unique. Made a spot and stalk one shot kill on another black bear with this one, and quite a few blue grouse.
While antelope hunting in eastern Montana, I'll sometimes carry a Ruger single six .22 LR that has only killed one rattlesnake and one coyote.
This year I bought a S&W 4" model 629 SS to carry instead of one of my 7 1/2" SBH's. It shoots my 250 grain cast bullets well, and it is a joy to shoot with 250 grain Lyman 429244 .44 Spl loads. I'll be carrying it this fall on hunts in Montana and Alaska.