So much depends on the initial choice you make. Then throw in what really amounts to the witchcraft of reloading, that intangible bit that makes all the components put together achieve everything you hoped while it gets logged as never try this again in my book.
Generally speaking I don’t push the limits and in a great many rifles found my best accuracy somewhat below max, particularly with older powders, like 4350. I also had to hammer open a bolt on a 30/06 when I was 13 or 14 years old, nearly 60 years ago. That lesson stuck with me.
I have found that some of the “newer” powders shoot better for me at the high end, Rl 17 and 26 come to mind, however I generally tap out before going much over 60k pressure. If a 22 Hornet isn't doing what I need I buy a .22-250.
I’ve owned and loaded for a rifle in just about every niche from 22 hornet to 577 NE. All those lessons taught me if I see pressure to back off and if needed try a different combination.