Go with the heaviest, sharpest broadheads you can safely shoot. You want the weight/momentum to help with a passthrough, and the sharper broadheads to cause the most bleeding with the least resistance- resistance causes clotting. Look into getting a razor strop with polishing compound for that mirror-finish edge, which will slice through anything and stay clean while doing it.
I used to shoot 100gr thunderheads on whitetail, and I now have QAD Exodus 100gr.
I'm looking at upgrading my arrow/broadhead setup to a 500+ gr package with a two-blade, single bevel when I have the time/budget for it.