I'll give a better response, from a SE perspective.
The pan handle doesn't have the species that the interior has. (Caribou, Sheep, Moose) Most of my buddies (who live in the same small town as me in SE make a yearly pilgrimage up north to pursue those species though, and do quite well. The advantage of residency. It costs money though, or 15,000 AK air miles to get to anchorage.
What SE does have are sitka blacktails, black bears, brown bears, mtn goats, elk, and moose. (elk is drawing, moose isn't very good). Vast public lands in SE AK. Not many hunters.
Where SE shines in the saltwater fishing. It's what keeps me here. I can run out in the evening and catch limits of kings and halibut, all within sight of my house. A boat is a must in SE AK. River fishing is very good too for trout, steelhead, and salmon. No combat fishing. Easy access.
It rains a ton in SE. I think my area gets 120" a year. I don't mind, most people do. It keeps the population down.
I've watched people come and go from SE AK for 10 years now. Most people who hate it don't put for the effort to do much hunting/fishing. Those that do absolutely love it. Have the means to make that yearly pilgrimage up north to do your moose/caribou/sheep hunting, and SE AK ain't a bad place to live. It's all the benefits of Alaska, without having to deal with lots of snow and people.