I'll second what Bambi suggested. If you do want to go to Denali and see wildlife, you'll want to take a bus trip. You can drive the first 13 miles of the park road with your car but its mostly moose habitat in that area, better bear and caribou habitat is beyond that point. If you're more the DIY type person, I would avoid taking a bus as you'll be stuck on it with 50 of your closest tourist friends ALL DAY LONG. Not much to see or do in Talkeetna really, its just a hub for tourists going to and from Denali by bus or train.
The Parks Highway between Anchorage and about an hour north of Talkeeta is one of the most boring in Alaska. Low probability of seeing wildlife in this stretch. It gets better up around Broad Pass and Cantwell. If you want a more relaxed, self-paced tour of AK, take the Denali Hwy (the gravel road) across from Cantwell to Paxson. Do this route west to east and get the boring section of the Parks Hwy over with first. Once in Paxson, take a short detour north on the Richardson Hwy up to Black Rapids. Neat area and you'll likely see bison with their newborn calves out on the Delta River gravel bars. Then go south to Valdez, stopping at the Chitina / Copper River area to see subsistence fish wheels in action. You won't see this anywhere else in AK on the road system. You'll also see personal use dipnetting for sockeye in this area.
The ferry ride from Valdez to Whittier is 3 hours. You'll likely see whales, Dall porpoises, and sea otters. As Bambi suggested, Seward offers a better fishing option over Ninilchik if you're looking to bring home more meat. Wildlife viewing out of Seward is far better than Ninilchik. Seward will offer whales, orcas, sea lions, sea otters, sea birds, Dall porpoises, and mt. goats. About all Ninilchik will offer is some sea birds and maybe a beluga whale if you're really lucky. Farther down in Cook Inlet the wildlife viewing gets better (from Homer south).
If you need to kill some time, stop by Cooper Landing and check out the combat fishing at the Russian / Kenai River confluence. Not an aspect of AK fishing you'll see on the Outdoor Channel. A good 2 hr side trip out of Seward is to hike up to Exit Glacier, look for mt. goats and black bears on the slopes. Stop along Turnagain Arm to see Dall sheep.
Good luck,
Jeff