Depends how far you're shooting. Over 300 yards I'd start paying attention. The bullets ability to maintain velocity is nice, but with modern scopes and rangefinders, it's not quite as important as it once was.
I think the more important piece is it's resistance to wind drift. That's more of the wild card with long range shooting. Elevation is easy compared to wind drift. More forgiveness on wind calls would be more beneficial in my opinion!
Here's some #s I pulled for my 338 Win Mag.
230gr ELDX (.616 BC) - 800 yards @ 2,840 FPS
7 mph wind - 3.92 MOA
10 mph wind - 5.31 MOA
Difference of 1.39 MOA (11.68 inches off)
185gr CX (.407 BC) - 800 yards @ 3,080 FPS
7 mph wind - 5.39
10 mph wind - 7.36 MOA
Difference of 1.97 MOA (16.55 inches off)
A higher BC is a little more forgiving in this scenario, by about 5 inches.