Covid-19 - Emerging treatment news thread (no politics, no tin foil hats)

[SD_Prairie_Goat]

South Dakota is starting to clinical trial, sounds like it is going to be for both sick people and those that have been exposed but not yet shown any symptoms.

South Dakota first state for COVID-19 clinical trial treatment and prevention

SIOUX FALLS, S.D. (KELO) — Governor Kristi Noem announced Monday that Sanford Health will lead a clinical trial investigating the drug hydroxychloroquine for the treatment and prevention of C…

www.keloland.com

 

[jryoung]

jryoung, how is the testing going? Anything you can tell us yet?

I'm clean
On a more serious note once we get a better understanding of what we can communicate I'll provide an update. It seems easy enough we could say something like we've tested X and have had Y% return some sort of positive result.....but nothing is "easy" or very clear right now.

 

[huronmtns]

Latest update:

 

[LWC55]

Major League Baseball Joins The Fight Against Coronavirus In A Big Way

Major League Baseball plans to test up to 10,000 players, employees and their families to detect COVID-19 antibodies. The hope is to see how prevalent the infection rate is in the general population.

www.npr.org

 

[VikingsGuy]

Every Vaccine and Treatment in Development for COVID-19, So Far

As the number of confirmed COVID-19 cases continues to skyrocket, healthcare researchers around the world are working to defeat the virus.

www.visualcapitalist.com

 

[Paul in Idaho]

Early peek at data on Gilead coronavirus drug suggests patients are responding to treatment

A Chicago hospital treating severe Covid-19 patients with Gilead's remdesivir is seeing rapid recoveries in fever and respiratory symptoms, STAT has learned.

www.statnews.com

 

[VikingsGuy]

Early peek at data on Gilead coronavirus drug suggests patients are responding to treatment

A Chicago hospital treating severe Covid-19 patients with Gilead's remdesivir is seeing rapid recoveries in fever and respiratory symptoms, STAT has learned.

www.statnews.com

Been a mixed bag so far for this and hydroxyquinolone.

 

[Paul in Idaho]

Been a mixed bag so far for this and hydroxyquinolone.

Agreed. My understanding is this is the first clinical study data in the US. I chose that article to share since it contains caveats about the news, including:

The outcomes offer only a snapshot of remdesivir’s effectiveness. The same trials are being run concurrently at other institutions, and it’s impossible to determine the full study results with any certainty
...
“It’s always hard,” she said, because the severe trial doesn’t include a placebo group for comparison. “But certainly when we start [the] drug, we see fever curves falling,” she said.
...
“So if it’s true that many of the 113 patients were in this category and were discharged, it’s another positive signal that the drug has efficacy,” he said, adding that it will be important to see more data from randomized controlled studies.
...
The lack of a control arm in the study could make interpreting the results more challenging.
...
In scientific terms, all the data are anecdotal until the full trial reads out, meaning that they should not be used to draw final conclusions.

 

[LWC55]

Good discussion of c-19 and big picture medical response with Dr. Katz of Yale.

 

[LWC55]

Far more people may have been infected by coronavirus in one California county, study estimates

Far more people may have been infected with Covid-19 than have been confirmed by health officials in Santa Clara County, California, according to a study released Friday in preprint.

www.cnn.com

The study estimated that 2.49% to 4.16% of people in Santa Clara Country had been infected with Covid-19 by April 1. This represents between 48,000 and 81,000 people, which is 50 to 85 times what county officials recorded by that date: 956 confirmed cases.

"If I get the infection, how likely is it I'm going to die? That number depends on knowing how many people have had the infection -- not just actively have it now, but have had it and recovered from it," Bhattacharya said.
If 50 times more people have had the infection, the death rate could drop by that same factor, putting it "somewhere between 'little worse than the flu' to 'twice as bad as the flu' in terms of case fatality rate," Bhattacharya said.

 

[3855WIN]

Sunlight kills virus.

Sunlight destroys virus quickly, new govt. tests find, but experts say pandemic could last through summer

Preliminary results from government lab experiments show that the coronavirus does not survive long under high-temperature, high-humidity conditions, and is quickly destroyed by sunlight, providing evidence from controlled tests of what scientists believed — but had not yet proved — to be true.

news.yahoo.com

 

[BigHornRam]

Working for monkeys.

RML researchers: Experimental antiviral slows progression of COVID-19 in monkeys

An experimental antiviral medication significantly reduced clinical disease and damage to the lungs of rhesus macaques infected with the virus that causes COVID-19, according to a study completed at Hamilton’s

mtstandard.com

 

[jryoung]

Good discussion of c-19 and big picture medical response with Dr. Katz of Yale.

Dr. Katz was my wifes PH&E professor. By far more than 20 years later, he is the one educator she talks about the most.

 

[LWC55]

Dr. Katz was my wifes PH&E professor. By far more than 20 years later, he is the one educator she talks about the most.

He seems like a very smart and even more level headed guy. Wish we had more like him. He appears to truly have the overall health of America as his number one goal.

 

[----]

Dr. Katz was my wifes PH&E professor. By far more than 20 years later, he is the one educator she talks about the most.

You left this very open ended.

 

[LWC55]

Global Covid-19 Case Fatality Rates - The Centre for Evidence-Based Medicine

The total number of cases and the total number of deaths from COVID-19 outbreak data was drawn down (scraped) from Worldometers.

www.cebm.net

Taking account of historical experience, trends in the data, increased number of infections in the population at largest, and potential impact of misclassification of deaths gives a presumed estimate for the COVID-19 IFR somewhere between 0.1% and 0.36%.*

 

[Rainer]

I would stop looking at any information coming out of the States and focus more on South Korea. If any vaccine is going to be developed it will be by them or the Germans. They are actually focused on finding one that will benefit humanity and not shareholders, their leaders won't rush something for political gains, they taking this pandemic seriously and have proper leadership. The sad thing is, that it's at least 12-18 months away. Thousands more will die. If any one is bored though the beaches in Florida are now back open. They're crowded so get there early lol

 

[Treeshark]

They are actually focused on finding one that will benefit humanity and not shareholders

I understand your point, but global medical innovation as a whole over the past several decades proves that those two things are not mutually exclusive.

 

[3855WIN]

The USS Roosevelt had a crew of around 4,800. Around 600 tested positive, and around 60% that had it showed no symptoms. 5 hospitalized and one death. This appears to demonstrate that the risk to young people is fairly low. Schools and sports leagues should be able to open.

Coronavirus clue? Most cases aboard U.S. aircraft carrier are symptom-free

Sweeping testing of the entire crew of the coronavirus-stricken U.S. aircraft carrier Theodore Roosevelt may have revealed a clue about the pandemic: The majority of the positive cases so far are among sailors who are asymptomatic, officials say.

www.reuters.com

 

[jryoung]

You left this very open ended.

Like, she spent a lot of time in office during office hours and earned an A? LOL

Or more like, the year she had him as a professor and doing clinical rounds at Griffen had the most significant impact on the way she approaches medicine and her patients today.