I've taken about forty plus big game animals with the 25-06 Rem and 25-06 Ackley Improved. (same rifle, just rechambered it). You will be extremely unhappy with the 120g Nosler Partition, unless you shoot a Cape Buf. with it. I used it for a couple of years and never got it to expand well, even on very large Muleys. Both the 100g Nosler Partitions and the 100g Ballistic tips didn't work well either. The ballistic tips blew to pieces upon impact, just as bad as any of the sierra bullets do, maybe even worse. The 100g Nosler Partitions kill "well" but leave football sized exit holes, even on larger Muleys. It really screws up a cape. The Hornaday interlocks (all of them) didn't expand hardly at all, like the 120g Nosler Partition. Not even the 100g ones. The 115g Nosler Partition kills like lightening. Always! I shot an Ibex at 600yds (actually a little more) angling away. The bullet entered through the left hind quarter and exited the right front shoulder. Pretty good penetration, huh. A 2-2 1/2 inch exit hole too. Shot a huge bodied Muley at 50 yds, same results. Shot a pronghorn at 350 yds plus a little, same results. Etc...etc... Nothing works as good. My son took a large Quebec-Labrador Caribou Bull and a real nice 6X6 Bull Elk with the same loads. One shot kills on both. Because of what me and my sons and my father have killed with the 25-06s with the 115g Nosler Partitions, everyone I hunt with has bought 25-06s and shoot the 115g Nosler Partitions through them. Everyone gets the same results! DEADLY! Also, after loading over 20,000 rounds of 25-06 Rem. and 25-06 Ackley Improved ammo. That's not an exaggeration on the figures. I load the ammo for everyone in my family and several of my hunting partners. There's only one powder to use in the 25-06 Rem. or the 25-06 AI. Use IMR7828. It's given the best results in about ten or more such rifles. The highest velocity and the finest accuracy. You'll see what I mean, try it!