I made the drive about 5 years ago. Had a freezer full of deer & pheasants - no problem - declare it at the US customs & got "inspected" (agent went into the 5th wheel & checked out guns & mounts) - everything was ok. Canadian customs was hand in firearms transport form, pay fee & go. Long guns are easy to transport, download the form from Canadian government website. Handguns (some) can be transported, but more hoops to jump through. I'd check w/ferry and send them with your wife. If you have a pet with you be sure to have a current health form with you for the pet. At the time I made that trip, the only bad road was between Whitehorse & Tok - lots of the aforementioned frost heaves. Road conditions change with every winter and subsequent construction season. The Milepost is invaluable. Call ahead to figure out where you'll be able to overnight (I'd start setting this up about 2 weeks before you go). Between Labor Day and Memorial Day, lodging may be hard to find. Most major credit cards (Visa & MasterCard) will work most everywhere. If you roll with cash, get Canadian $ before the trip. Some border crossings have exchanges at the border.
There are pockets along the highway where you may spot game (depending on when you travel), but its mostly miles and miles of spruce & birch. On our trip we saw: elk (YK), woods bison (BC) - be careful driving, they aren't afraid of vehicles and locals say there are lots of accidents involving the buffalo, a grizzly (YK), black bears (BC), caribou (YK), stone sheep (BC). Some were seen in October (heading south) & some in May (headed north). All in all, its a great trip, but you probably won't want to repeat it too soon.
