Whoa, man, this is a philosophical question, much like debating whether the universe is, in any way, truly stochastic or if it all fixed and fated determinism.
Let's just say that it is undebatable that the ESA extends to unique subspecies and populations. For instance, the Mt. Graham Red Squirrel in SE Arizona is an ESA, though it is the same species as the red squirrel found from Alaska to Massachusetts. The Alabama Beach Mouse is another - though it is one of 5 sister subspecies of beach mice (all but one Endangered) and the very common interior Old field mouse. They are all in the species
Peromyscus polionotus.
No, - well yes, it is easy to describe with DNA analyses, this can be quantified and Bison vs cows, Wolves vs dogs, and Wolf vs Fox are simple. But when we get into flavors of wolves, things get messy because it becomes more like a gradient than well defined clusters. The problem isn't in quantifying the differences, but rather, drawing the lines in the sand.
Just for instance, y'all are part Neanderthal and almost certainly, y'all could still breed with them if they were still around (and if they'd have ya ---

). But that doesn't make them
Homo sapiens nor us
Homo neanderthalensis.
Suffice it to say, if you think you are going to do an end run around the ESA based on the possible (is this really a fact) minor genetic intrusion of domesticated bovine jeans, you are wasting your time, and mine, and everyone else's. It's been tried on far foggier species delineations than this and face planted every time.
You could do yourselves a favor if you threw out the ultra-simplistic definition of biological species that you learned in high school. It just doesn't work very well when getting down to the nuts and bolts of real-life biology.